The human hair follicle is a highly proliferative tissue system with unique and complex energy needs to grow hair. This PhD project will examine the links between metabolism and proliferation in human hair follicles, including within epithelial stem and progenitor cell populations. The aim of the project will be to examine how exactly metabolism influences the cell cycle in the hair follicle, and whether periods of hair follicle proliferation and quiescence are reflected by changes in metabolic pathways and tissue energy requirements.
The PhD student will examine this link over the course of the hair follicle cycle (i.e. anagen, catagen and telogen), during conditions of stress, and in states of hair follicle pathology (e.g. inflammatory hair loss conditions). This research will help unravel key molecular and cellular drivers of hair growth, and will work to determine how metabolic pathways might be deregulated in hair loss conditions, together potentially offering new treatment approaches to promote hair growth and manage hair loss. The project will link to our broader research themes in hair follicle biology and inflammatory hair loss disorders, and will be supported by strong links with our dermatology/hair loss clinics based at the Northern Care Alliance NHS group.
Entry Requirements
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience are particularly encouraged to apply.
How To Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”
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