Applications will be reviewed until a suitable candidate is appointed.
The burden of antimicrobial resistance is a daily challenge in clinical settings, especially in acute and intensive care units. In burn units, it is estimated that more than 75% of deaths are associated with infections, and a key bacterial pathogen contributing to such infections is Pseudomonas aeruginosa. On the burn surface, microorganisms commonly exist within a complex, multispecies structure termed a biofilm, which enhances bacterial resistance to antimicrobial agents. Many of these bacteria are becoming multi drug resistant, which is the main driving force behind the development of new strategies and technologies to tackle such infections, including the design and applications of new metal surfaces and metal nanoparticle-based biocidal agents. However, how such biocidal products affect the biofilm consortium, their metabolic response and metabolome, and the resulting virulence and resistance of the bacteria is unclear. Such biological understandings may support may provide important clues to prevent a mismatch between therapeutic strategies, facilitate desirable prognosis and reduce the risk and development of antimicrobial resistance.
In this project, you will be using various microbiological culturing techniques, and the state-of-the-art metabolomic approaches (Raman and infrared spectroscopies, and mass spectrometry) to monitor changes in the metabolic profiles and response of the bacterial cells upon exposure to various metal NPs and surfaces.
The multidisciplinary nature of this project will give the successful candidate a broad training in modern biology techniques including omics, microbiology, experimental design, bacterial biochemistry, and various multivariate statistical methods. Both laboratories involved in this collaborative project have researchers from a range of backgrounds, countries and disciplines, hence alongside learning the research techniques and transferable skills, the student will engage with a range of students and postdoctoral scientists and will actively see how research is translated into industrial and clinical pathways.
For enquiries or to express your interest in this position, please contact: Dr Howbeer Muhamad Ali on: [Email Address Removed]