About the Project
By combining the programmability of natural biopolymers such as DNA with the robustness and functionality of synthetic systems, next-generation hybrid polymers inspired by nature can be constructed with unprecedented features. This PhD project, involving a collaboration between the University of Melbourne (Prof Amanda Ellis) and the University of Birmingham (Prof James Tucker), involves the design and construction of metal-containing DNA hybrid materials that display novel redox properties for a variety of biomedical applications.
The student will synthesise monomeric DNA-based components and then polymerise them into new DNA-hybrid nanomaterials. He/she will study their properties using a range of spectroscopic and analytical methods and become proficient in a range of techniques including: small molecule synthesis; DNA and polymer synthesis and characterisation; spectroscopy (e.g. UV/vis and CD); electrophoresis; electrochemistry. He/she will have an interest in or experience of one or more of the following topics: synthetic chemistry, self-assembly, polymer chemistry, supramolecular chemistry, biochemistry or chemical biology, analytical chemistry.
Interested candidates should contact Prof Amanda Ellis or Prof Jim Tucker in the first instance by email, attaching an up-to-date CV.
Prof Jim Tucker can be contacted via [Email Address Removed].
*subject to inflationary variation, with a comparable rate for students who are to be hosted by the University of Melbourne.
2) Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA, J.L.H.A. Duprey, J. Carr-Smith, S.L. Horswell, J. Kowalski, J.H.R. Tucker, J. Am. Chem. Soc., 2016, 138, 746-749, https://doi.org/10.1021/jacs.5b11319
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