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Methodology of Clinical Tests for Assessment of Cerebral Autoregulation after Traumatic Head Injury

Department of Clinical Neurosciences

Thursday, December 03, 2020 Competition Funded PhD Project (Students Worldwide)

About the Project

Various methods exist for assessment of autoregulation of Cerebral Blood Flow (CBF). They incorporate different modalities: arterial blood pressure, intracranial pressure, blood flow velocity, cerebral perfusion pressure, and brain tissue oxygenation (1). Dynamical tests of cerebral autoregulation include time series analysis, analysis of models based on transfer function, wavelet decomposition, non-linear decomposition, etc. The aim of the project is to compare various methodologies, various modalities and compare them from the point of view of clinical utility in a group of head injured patients. Strong emphasis will be put on feasibility studies of new and existing methodologies at the bedside: such as a concept of ‘optimal’ Cerebral Perfusion Pressure or individualized threshold of intracranial pressure. Also links between brain physics modalities and electrophysiology and biochemistry will be of interest Project is ideal for a person having medical or biological background with strong practical computer skills.

Funding Notes

Funding deadline is 3rd December 2020 for start in October 2021. When applying indicate on the application the funding options (GATES USA *deadline 14/10/19*, Gates Cambridge or other Cambridge Funders). Home/EU and International applications are all considered for funding.


Further readings (4). 1. Czosnyka M et al. Neurocrit Care. 2009;10(3):373-86. 2. Aries MJ et al. Crit Care Med. 2012; 40(8):2456-63. 3. Lazaridis C et al. J Neurosurg. 2014 Apr;120(4):893-900. 4.

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