Microbiome metagenomics, senescence and mortality in an island population of birds (RICHARDSONU21DTP)

This novel and exciting project will use metagenomics to investigate compositional and functional changes in individual gut microbiome (GM) linked to health, senescence and mortality in the Seychelles warbler.

Studies on humans and domestic/captive animals have shown that the vertebrate GM – a complex microbial community comprising thousands of species – plays a role in fundamental processes within the host and suggests that differences in the GM can have considerable impacts on health and ageing. However, captivity (and medical/health interventions) can radically affect the GM and confound such studies. Detailed studies that measure how the GM changes within individuals over time in wild-living vertebrate populations are needed to fully understand the role of the GM.

Our long-term monitoring of an island population of Seychelles warblers, where individuals are measured and sampled throughout their lives, provides a unique opportunity to undertake a study on the GM without the confounding issues of unnatural conditions or medical interventions. We already have samples and accurate health and survival data on 100’s of individuals and previous work confirms that considerable variation in senescence, survival and GM composition occurs. This population therefore provides the samples, data and resolution for an excellent, ground-breaking study.

This PhD offers an exceptional training opportunity, working on cutting-edge conceptual questions within a world-class research environment. You will gain a wide range of research skills including sequencing, metagenomics, bioinformatics, database use, and statistical modelling. There will also be a fieldwork component. You will also receive excellent general training from the Norwich Biosciences Doctoral Training Partnership based at UEA, supervised by Prof David S Richardson (UEA) and Dr Falk Hildebrand (Quadram/Earlham Institute), with support from Prof. Matt Hutchings (JIC) and Dr Hannah Dugdale (Groningen).

https://people.uea.ac.uk/david_richardson
https://quadram.ac.uk/people/falk-hildebrand/
https://www.jic.ac.uk/people/matt-hutchings/
In collaboration with overall Seychelles Warbler Research Project.
http://seychelles-warbler-project.group.shef.ac.uk/
https://www.rug.nl/staff/h.l.dugdale/?lang=en

This is a PhD programme.

The start date is 1st October 2021.

The mode of study is full time.

The studentship length is 4 years.


About NRP DTP:

The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to UK and international candidates for entry October 2021 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Thursday 7th January, Friday 8th January and Monday 11th January 2021.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.