Microdevices to investigate sleep and temperature regulation in mice
Prof N Franks
Dr T Constandinou
No more applications being accepted
Funded PhD Project (European/UK Students Only)
(4 year MRes + PhD studentship)
This project is one of 11 studentships starting in October 2016 in the Imperial College EPSRC Centre for Doctoral Training in Neurotechnology for Life and Health - https://www.findaphd.com/search/PhDDetails.aspx?CAID=2386
Supervisors: Nick Franks (Life Sciences), Tim Constandinou (Electrical & Electronic Engineering), William Wisden (Life Sciences)
Sleep is essential for all animals, yet its specific function is unknown. Moreover, the overlap between the neuronal circuitry underlying sleep, the actions of sedative drugs, and temperature regulation is a mystery. Because of the power of genetics, mice are ideal animals to investigate sleep and temperature regulation, yet their small size makes recording brain waves and temperature a challenge. This project will develop two microdevices, one that will allow continuous recording of these parameters over many days, and the other will allow the brain temperature to be clamped, so that the impact of temperature can be investigated in both sleep and sedation.
The CDT programme is not a standard PhD programme. Throughout the 4 years, there is considerable emphasis upon multidisciplinary and transferable skills, through centre activities beyond the individual research project. The programme cannot be taken without the first (MRes Neurotechnology) year, as it is an integral part of the overall programme.
Applicants should have (or expect to obtain) a first or upper second class degree (or non-UK equivalent) in an engineering or physical science subject. Students with a biological and medical sciences background may be considered, but candidates must have sufficient quantitative skills to thrive in the programme. You should be looking for a challenging, multi-disciplinary PhD at the interface of neuroscience and engineering.
To apply online, visit www.imperial.ac.uk/neurotechnology/cdt/apply/
If you have questions or would like further information about the project, we encourage you to contact the supervisors directly before making your formal application.
Studentships pay UK/EU tuition fees, stipend and a generous consumables and travel fund for the duration of the programme (one year of MRes and 3 years of PhD).
Places are open to UK and EU applicants only.
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