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Microfluidic-assisted manufacture of silk nanoparticles for anticancer drug delivery (nanomedicine)

Project Description

This project is one of 9 four-year PhD Studentships funded by Medical Research Scotland ( to be delivered jointly by the named University and Company. The Studentship will provide the first-class academic and commercial training needed to equip the successful candidate for a science career in an increasingly competitive market.

"Microfluidic-assisted manufacture of self-assembling silk nanoparticles" to be delivered by the University of Strathclyde [Supervisors: Dr Philipp Seib and Professor Yvonne Perrie (both Strathclyde Institute of Pharmacy and Biomedical Sciences)] and Precision NanoSystems Inc ( [Company supervisors: Dr Anitha Thomas and Dr Richard Broadhead].

Are you someone with a passion for science and working across scientific interfaces? Are you ambitious, self-motivated with the skills to develop new ideas and use nanotechnology to generate big ideas? Are you a UK/EU student who has at least an Upper Second Class Honours degree in a biological or chemical science or a related subject and looking for an opportunity to travel and work across academic and industrial sectors? Then this PhD is an ideal opportunity for you.

We are looking for applicants to join our exciting new collaboration that will create innovative silk-based nanoparticles using new microfluidics based manufacturing technologies. This project is a cross-disciplinary collaboration involving Dr Philipp Seib, an expert in silk and nanomedicines, Professor Yvonne Perrie, an expert in drug delivery and Precision NanoSystems a world leader in enabling Precision Medicine by providing a complete, cost-effective and accessible solution for the discovery and development of molecularly tailored and targeted medicines.

By joining this collaboration, you will gain from a world-class research programme in the fields of biopolymers, drug delivery, cancer formulation and microfluidics. As a PhD student you will join the Strathclyde Institute of Pharmacy and Biomedical Sciences, a leading centre for research and training focused on the discovery, development and delivery of better medicines. Our campus is based right in the very heart of Glasgow. National Geographic named Glasgow as one of its ’Best of the World’ destinations, while Rough Guide readers have voted Glasgow the world’s friendliest city.

Applicants must have obtained, or expect to obtain, a first or 2.1 UK honours degree, or equivalent for degrees obtained outside the UK, in a biological or chemical science.
Funding covers UK/EU students only

Applicants should send a CV, the contact details of 2 references (including email addresses) and a covering letter, explaining why the applicant wishes to carry out this project, all in one pdf document by email (Dr Philipp Seib).
Subject line: MRS PhD applicant
Email address:

Please note, your application may be shared with the funders of this PhD Studentship, Medical Research Scotland and Precision NanoSystems Inc.

Interviews are expected to take place Wednesday 27 February.

It is anticipated that the PhD Studentship will start in October 2019.


Enquiries should be sent by email to Dr Philipp Seib:

Funding Notes

PhD Studentship provides:

An annual tax-free stipend of £17,500, increasing to £18,000 over the four years; tuition fees at UK/EU rates only; consumables; and contribution to travel expenses. Covers UK/EU students only, international fees are not covered.


Wongpinyochit T, Totten JT, Johnston BF, Seib FP (2019). Microfluidic-assisted silk nanoparticle tuning. Nanoscale Advances doi:10.1039/C8NA00208H

Holland C, Numata K, Rnjak-Kovacina J, Seib FP. The biomedical use of silk: past, present, future. Advanced Healthcare Materials (2019) 8:e1800465

Totten JD, Wongpinyochit T, Seib FP (2017). Silk nanoparticles: proof of lysosomotropic anticancer drug delivery at single-cell resolution. Journal of Drug Targeting 25, 865–872

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