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Microfluidic enabled high-throughput single molecule imaging in cyanobacteria


Project Description

This project will develop and apply cutting edge microfluidics and single
molecule super-resolution microscopy to rapidly advance our understanding
of cyanobacteria protein cellular distribution, abundance and dynamics.
Cyanobacteria account for ~10% of global carbon fixation and are a
promising industrial biotechnology platform for high-value products.

Synechococcus elongatus PCC7942 is a model cyanobacteria for
understanding photosynthesis and is widely applied in synthetic biology
applications, however 40% of its genes have no functional annotation. To
address this, we have recently developed a high-throughput fluorescence
protein tagging pipeline and have over 300 GFP tagged lines. This project will
combine a microfluidic platform with single molecule super-resolution
microscopy to rapidly image this collection under a range of different
conditions to give novel insights into cyanobacterial CO2 uptake and
photosynthesis. It is a highly multidisciplinary project with the successful
candidate working with groups in the Department of Physics, Department of
Electronics and the Department of Biology.

We are interested to hear from students interested in one or more of the
following areas: biophysics, microscopy, microfluidics, molecular biology,
photosynthesis

More details on the Leake lab and be found here: http://single-molecule-
biophysics.org/ and the Mackinder lab here: http://www.mackinderlab.com

Funding Notes

This is a BBSRC White Rose DTP studentship fully funded for four years and covers: (i) a tax-free annual stipend at the standard Research Council rate (£15,009 estimated for 2020 entry), (ii) research costs, and (iii) tuition fees at the UK/EU rate.

References

Entry requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this research project means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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