Microfluidic devices offer precise control of mixing multiple fluids in microscale, enabling fabrication of advanced nanoparticles/liposomes with tuneable sizes and compositions in a high throughput and repeatable manner. A combination of these remarkable features with carefully selected materials and fabrication conditions enables high efficiency, direct encapsulation of actives in nanoparticles/liposomes with well controlled functionalities. This PhD project is to use a newly designed microfluidic device to fabricate/formulate/functionalize nanoparticles/liposomes for drug and gene delivery. The student will be trained to use the microfluidic device for particle fabrication, use modern techniques such as AFM, SEM, TEM, FTIR, DLS/nanosight, CD Spectroscopy to characterize the properties of the particles and use Flow Cytometry, Confocal Laser Scanning Microscopy (CLSM) etc. to evaluate the toxicity and drug/gene delivery efficacy.
Please see this link for information on how to apply: https://www.sheffield.ac.uk/cbe/postgraduate/phd/how-apply. Please include the name of your proposed supervisor and the title of the PhD project within your application.
Candidates should have a 1st class or 2.1 degree or MSc (merit or distinction) in chemistry, materials, pharmacy, biotechnology, bioengineering, biomedical engineering, chemical engineering or a related discipline. If English is not your first language then you must have an International English Language Testing System (IELTS) average of 6.5 or above with at least 6.0 in each component, or equivalent. Please see this link for further information: https://www.sheffield.ac.uk/postgraduate/phd/apply/english-language.