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Microfluidic platform for modelling of vascular changes in pulmonary arterial hypertension

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  • Full or part time
    Dr Beata Wojciak-Stothard
    Prof C Lloyd
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Pulmonary arterial hypertension (PAH) is a severe and currently incurable disorder characterized by progressive narrowing of small pulmonary arteries, leading to right heart failure. No single animal model can accurately reflect pathology of human PAH, severely limiting evaluation of drug treatment and characterization of disease mechanisms. Microfluidic devices are now being used to replicate physiological features of living human organs.

In this project we plan to develop a new microfluidic platform, which will allow simultaneous observation of different cell types interacting with vascular endothelium in arterioles and distal capillaries, altered in PAH. This multidisciplinary translational project will establish a model of lung peripheral vasculature with alveoli, using cells from PAH patients and healthy individuals, important in personalised medicine and drug testing.

The student will learn numerous cell biology, molecular biology (i.e. imaging, mediator analysis, gene expression analysis, manipulation of cells via oligos/siRNA/viral vectors and pharmacological agents) and nanofabrication techniques.

To apply, you will need to complete the following two steps:

1) Please email Veena Dhulipala ([Email Address Removed]) with the following documents.

- Your CV
- The names and addresses of at least two academic referees
- A personal statement of no more than 1,000 words explaining your interest in the project

2) Please complete the Imperial College London’s online application site (https://imperialuk.elluciancrmrecruit.com/Apply/Account/Login).

Please note that you will have to complete both steps for your application to be considered. Please assume that your application has not been successful if you have not heard from us within a month of the closing date.

Closing date for all applications: 23.59 on Sunday 19th January 2020

Interviews will be held in early February 2020

Funding Notes

Applicants must hold, or expect to obtain, a first or upper second-class honours degree or equivalent in an appropriate subject from a recognised academic institution. Candidates must fulfill College admissions criteria and meet BHF residency requirements.

We are looking for an enthusiastic individual with strong interest in cardiovascular biology, microfluidics and translational medicine. This is a highly interdisciplinary project and previous theoretical and practical experience in at least one of the areas of study is essential. Experience in cell culture, qPCR, western blotting and imaging techniques is desirable.

Related Subjects

How good is research at Imperial College London in Clinical Medicine?

FTE Category A staff submitted: 334.18

Research output data provided by the Research Excellence Framework (REF)

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