About the Project
In the last two decades Nanomedicines (NMs) are being explored for their potentials in treatment of numerous diseases and especially for cancer. The market for nanoformulated medicines is growing at a significant rate, with an estimated market value of $15.8 billion in 2014 and forecasted growth to $44.5 billion by 2019. The outcomes of the project have the potential to confer significant benefits for future medicines development.
The aim of this project is to develop nanoparticles (NPs) by microfluidics that contain biologic molecules which will be provided by our industrial partner. Microfluidics is a technique which deals with flow of fluids within micron sized channels. It provides a platform where these NMs can be synthesized in a controlled manner enabling to tune their size, charge, polydispersity, and other surface fictionalization properties. In addition, the technique is energetically economical, easier to use, comparatively cheaper and faster, and also the molecules which hasn’t been incorporated in the particles can be reused.
The specific objectives of this work are as follows:
(i) Optimization and Synthesis of polymeric & lipid nanomedicines containing biopharmaceutical molecule(s).
(ii) Physicochemical characterization of the NPs.
(iii) Dose and time kinetics of the NPs in vitro.
(iv) Biophysics (simulation studies).
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