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Microfluidic Synthesis of Nanomedicines for the Delivery of Biologic Drugs

School of Pharmacy

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Dr D Lamprou Applications accepted all year round Self-Funded PhD Students Only

About the Project

Progress in drug design has led to the development of new molecules. However, the limited ability to selectively deliver these molecules at well-defined dosing regimens remains a significant challenge. Therefore, the development of effective therapies relies on the development of effective carriers that are nontoxic, able to carry a significant payload of the molecule, with high accuracy, and which allow combination therapeutic platforms.
In the last two decades Nanomedicines (NMs) are being explored for their potentials in treatment of numerous diseases and especially for cancer. The market for nanoformulated medicines is growing at a significant rate, with an estimated market value of $15.8 billion in 2014 and forecasted growth to $44.5 billion by 2019. The outcomes of the project have the potential to confer significant benefits for future medicines development.
The aim of this project is to develop nanoparticles (NPs) by microfluidics that contain biologic molecules which will be provided by our industrial partner. Microfluidics is a technique which deals with flow of fluids within micron sized channels. It provides a platform where these NMs can be synthesized in a controlled manner enabling to tune their size, charge, polydispersity, and other surface fictionalization properties. In addition, the technique is energetically economical, easier to use, comparatively cheaper and faster, and also the molecules which hasn’t been incorporated in the particles can be reused.
The specific objectives of this work are as follows:
(i) Optimization and Synthesis of polymeric & lipid nanomedicines containing biopharmaceutical molecule(s).
(ii) Physicochemical characterization of the NPs.
(iii) Dose and time kinetics of the NPs in vitro.
(iv) Biophysics (simulation studies).

Funding Notes

Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date

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