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Microfluidics based core-shell droplet generator: design, construction, drop characterization and bio-compatibility


Project Description

3DMed scales up well-established researcher driven and strategic organisational collaborations between University of Brighton (UoB), UK and York University (YU), Canada. The future collaboration will capitalise on the synergy between programmes of excellent research in engineering and biomedicine. The basic concept is to be able to design and construct a prototype of a personalised drug delivery system able to generate micro- or even a nano-pills, which can be printed using the concept of a droplet generator. The design is complex due to the fact that different fluids with different Newtonian and Non-Newtonian properties, need to be injected, layered or encapsulated into the product that should be formed. Also the interaction with the impacted surface is important and will be analysed during the PhD studies.

The student will design and build a microfluidic based core-shell droplet generator for generation of core-shell droplets of different sizes able to shuttle various bioactive principles ranging from biomolecules to living cells. This part of the work will be in collaboration with the York University, which will support a second PhD student for the construction of a micro-droplet generator. Furthermore, the student will develop a knowledge of interfacial phenomena and wetting to facilitate understanding of the morphological structure for impact of a complex, i.e. core-shell droplet, onto a surface. Different surfaces will be considered, i.e. smooth and homogeneous, or porous. Fluids with different properties will be also analysed. Characterization of the produced pills at different scales (from 5 micron to 2 mm) will be carried out.

The successful candidate will visit York University, Canada to acquire the necessary skills to build the droplet generator. The trips are likely to be for around two months in year 1 and a further two to three weeks in years 2 and 3.

Funding Notes

This is a three-year, full-time position, funded by the University of Brighton starting in April 2020. The funding will cover university fees, and a PhD stipend at the UKRI rate, £15,009 pa for 2019/20.

Students who meet UK/EU residency requirements only.

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