About the Project
In recent years, a new paradigm has arisen pointing to the role that the transfer of different RNA species may play in the process of cell-to-cell communication. Research conducted in our lab and others have shown such RNA transfer is taking place at the time of conception between a ‘good’ embryo and the mother leading to a successful implantation. Our aim in the current project is to understand if Extracellular Vesicles (EVs) are involved in dialogue between the embryo and the maternal tract and if microRNAs are transferred from embryo to endometrium which are able to affect the periconception environment.
Our laboratory is well experienced in different in vitro 3-dimensional culture system models of human implantation, EV research, RNA metabolic labeling and next generation sequencing. We provide a first class training environment for our students. In addition the Sheffield post-Graduate school provides our PhD students with training in many different transferable skills. Our industrial partner (SPD Development Company Limited) in this research project is a leader of development of pregnancy diagnostic technologies. Hence, the project will provide an excellent environment for the prospect PhD student in both academic and industrial training aspects.
Candidates must have a first or upper second class honors degree or significant research experience.
Interested candidates should in the first instance contact Alireza Fazeli, [email protected]
How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply
Please clearly state the prospective main supervisor in the respective box and select Oncology and Metabolism as the department.
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