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MicroRNAs in the Pathogenesis Adverse Cardiomyocyte and Endothelial Cell Remodelling in Insulin Resistance

  • Full or part time
  • Application Deadline
    Monday, December 16, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Project details:

Lipogenic diets-induced diabetes increases risk of cardiac stress and vascular dysfunction. Recent studies have established the pivotal role of non-coding microRNAs in the pathogenesis of cardiovascular disease (CVD). Our group have demonstrated that microRNA-378a (miR-378a), a cardiac-rich miRNA, was induced by high-fat/high-fructose diets which coupled with estrogen-related receptor gamma (ERR) to regulate mitochondrial fatty acid-oxidation and lipoprotein metabolism, leading to mitochondrial and endoplasmic reticulum stress and insulin resistance. Moreover, expression of miR-378a in cardiomyocyte was found to be downregulated myocardial infarction, which was accompanied by activation of ERRsignalling and mitochondrial dysfunction.

The objective of this project is to investigate miRsand ERRas key determinants underlying pathological cardiomyocyte and arterial endothelial cell (EC) remodelling in insulin resistance. Specific aims are to:

- Establish the miRNAs/ERRcircuit as a key determinant of cardiac mitochondrial integrity and metabolic remodelling.
- Explore the therapeutic potential of miRNAs inhibitor in CVD via the mediation of ERR

Significance:
Successful delivery of this project will establish the miRNAs/ERRcircuit as a key driver of CVD pathogenesis upon nutrient-surplus induced insulin resistance and lend support for novel pharmaceutical design.

This project will be supervised by Dr Qiaozhu Su of Queen’s University School of Biological Sciences/Institute for Global Food Security and Professor David Grieve of Queen’s University School of Medicine, Dentistry and Biomedical Sciences.

All applications MUST be submitted through https://dap.qub.ac.uk/portal/user/u_login.php.

Specific skills/experience required by applicants:

Experience on small laboratory animals (e.g. mouse and rat) and general molecular biological techniques (e.g. Immunoblotting analysis and Q-PCR) are essential for this position.

All applicants must meet the academic entry requirements: https://www.qub.ac.uk/courses/postgraduate-research/biological-sciences-phd.html#entry

Funding Notes

Only UK and EU students are eligible to apply. Before applying, it is strongly recommended that you read the full information on eligibility criteria available from DfE: View Website.

Please note in particular that not all successful applicants may be eligible to receive a full studentship (i.e. fees and stipend) - please read in detail the Residency and Citizenship requirements in the document linked to above.

How good is research at Queen’s University Belfast in Agriculture, Veterinary and Food Science?

FTE Category A staff submitted: 33.40

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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