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  Miniaturized fluidized bed bioreactor for bioprocessing

   School of Engineering

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  Dr Vladimir Zivkovic  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The technology of fluidized beds (FB) allows for the effective contact within multiple phases, thus having been widely applied in varieties of industrial process. Our group is the leader in micro-fluidized bed including their fundemantals but also application including carbon capture and some bioprocessing application.  In his project our expertise would be used to design and study a 3 phase mini-fluidized bed bioreactor for the characterization of cell culture on the millimetre scale. The project would be in collaboration with the Agency for Science, Technology and Research (A*STAR) of Singapore to utilize their excellent bioprocessing knowledge, skills and lab facilities. 

3D printing, a promising fast design-fabrication technique, will be utilized in this project to manufacture small scale fluidized bed bioreactor that provides non-rectangular geometry and complex geometry for optimization of bioproduction. Afterwards, hydrodynamic investigation and optimization of the mini-FB reactor will be conducted to obtain a novel and stable fluidic system for cell growth and related metabolic activities. 

Considering the potentials on applying 3D printing technique on fabrication of 3 phase miniaturized fluidized bed bioreactor, merits of biological and microbial research can be complemented. This research is aimed to design a novel 3D printed mini-FB bioreactor to characterize and optimize the cell cultivation from a small-scale respect. 

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains colleagues from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices. 

Biological Sciences (4) Engineering (12)

 About the Project