About the Project
The major mitochondrial folding chaperones HSP 90 and 60 work in concert with small helper proteins, with the latter ensuring that the final hurdles to attain the fully folded state are overcome. This project aims to understand the role played by small helper proteins in regulating the MPTP.
This project will have access to clinical collaborators who will help define the disease states to study. The student will develop excellent skills in cell biology, omics techniques, biochemistry and chemical/structural biology with access to state-of-the art equipment.
The project is suited to a student with at least a good B.Sc. Upper Second degree in chemical or biological sciences and an interest in understanding the molecular mechanisms of mitochondrial diseases.
Applicants are encouraged to contact the Principal Supervisor directly at an early stage to discuss their application and the project. Assistance will be given to those who are applying to international funding schemes.
Details of costs can be found on the University website: View Website
2. Baines CP and Gutiérrez-Aguilard M (2018) The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore, Cell Calcium, 73: 121-130.
3. Jane A Armstrong… Criddle DN (2018) Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift, J. Biol. Chem. doi: 10.1074/jbc.RA118.003200.
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.