Additional Supervisor: Prof Susan Francis, University of Nottingham
There is a global pandemic of type-2 diabetes. Diabetic cardiomyopathy is a well-recognised complication, which manifests with early alterations in left ventricular (LV) structure and function. Its pathophysiology and management remains poorly understood. This inter-disciplinary (Engineering, Cardiology, Physics) and cross-institution (Universities of Leicester and Nottingham) project aims to develop a state-of-the-art computational model of the heart in a healthy individual and those with diabetic cardiomyopathy. The starting point is a multi-physics based computational framework coupling the differential equations describing the constitutive behaviour of heart muscle, transmembrane potential, conductance and active stress leading to the contraction of the myocardium. Calibration of the constitutive model parameters will be carried out using cardiac magnetic resonance (CMR) imaging and electrocardiographic (ECG) data. The project will focus on the study of the nature of the active stress and its mechanical description as the current formulations are relatively simplistic. We will develop a direct coupling parameter which includes cardiac microstructure information for both healthy and diabetic patients. Development of an ex-vivo model of diabetic cardiomyopathy will increase our understanding of the pathophysiology of remodelling, and allow testing of potential therapies.
Project Enquiries to [Email Address Removed]
Programme enquiries to [Email Address Removed]
To apply please refer to