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Modelling CHO clonal phenotype variance for optimal bioprocessing platform design

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  • Full or part time
    Prof C M Smales
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A 4-year iCASE PhD Studentship between Biopharm Process Research at GSK (Stevenage) and the University of Kent is available to identify novel mechanisms through which to rationally re-design GSKs Biopharm Chinese hamster ovary (CHO) cell expression platform to meet the ever-increasing demands of a strengthening Biopharm portfolio. This exciting collaborative project is available to start in September 2018 and is funded through the BBSRC iCASE scheme. The project will use advanced screening, genome editing (e.g. CRISPR/Cas9)/synthetic biology and analytical technologies, to further develop an understanding of the cellular processes that limit and underpin cell metabolism, cell growth, recombinant protein product yield and quality. In turn, this understanding will be utilized to develop new CHO cell chassis and bioprocesses that enhance GSKs ability to rapidly generate cell lines making novel molecules at appropriate amounts and quality for investigation and progression towards clinical studies. The project will involve secondment to the GSK Stevenage site to undertake sections of the work. This is an excellent opportunity for a student to work with two world-class institutions to investigate cell biology, bioprocessing and recombinant protein production and be involved in the translation of the findings of research into industrial application.

Applications will be considered until the deadline of 23 April 2018. Interviews will be held at the GSK Stevenage site on a date to be confirmed.

To apply please go to

Perspective candidates should have (or expect to attain) a minimum of a 2/1 (Hons) degree in biochemistry, biology, biotechnology, biochemical engineering or a related field.
Informal enquiries can be addressed to: Prof Mark Smales [Email Address Removed]

Applications can be made using the online University application page where the project title should be entered as the proposed area of research and Prof Mark Smales as supervisor. Please include a CV and a cover letter.

Further scholarship details can be found at:

Applications must be received by: 23 April 2018

Funding Notes

Funding: The studentship will pay an annual stipend at the UK Research Council rate of £14,777 (rate for 2018/2019) and cover tuition fees at the rate for UK/ EU students. To be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for 3 years prior to the start of the programme (for EU applicants this includes time spent studying).

How good is research at University of Kent in Biological Sciences?

FTE Category A staff submitted: 24.20

Research output data provided by the Research Excellence Framework (REF)

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