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Modelling failure mechanisms in total ankle replacement

Project Description

Total joint replacement has been a successful surgical intervention for end-stage osteoarthritis for millions of patients globally for several decades. Despite this, clinical outcomes for total ankle replacement (TAR) have been comparatively poor – with up to 20% of implants failing before 10 years. As a result, TAR – an intervention which preserves joint function – has been used less commonly than ankle fusion – an intervention which limits ankle range of motion. Further understanding of how the ankle replacements are failing, and modelling of the potential mechanisms, will inform future implant design and development – which could provide a viable replacement implant for millions of patients globally.

This project aims to develop experimental simulation to model the mechanisms for failure of total ankle replacement through the following activities:
 -Morphological and geometrical analysis of failed total ankle replacements
- Definition of the  functional conditions for a total ankle replacement such as biomechanical function of TAR patients; implant alignment; tissue characteristics
- Development of an advanced experimental model that replicates the biomechanics of typical total ankle replacement and generates clinically relevant failure mechanisms

Funding Notes

UK/EU – Engineering & Physical Sciences Research Council Studentships paying academic fees of £4,600 for Session 2020/21, together with a maintenance grant of £15,285 for Session 2020/21 paid at standard Research Council rates for 3.5 years. UK applicants will be eligible for a full award paying tuition fees and maintenance. European Union applicants will be eligible for an award paying tuition fees only, except in exceptional circumstances, or where residency has been established for more than 3 years prior to the start of the course. Funding is awarded on a competitive basis.

Related Subjects

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FTE Category A staff submitted: 44.80

Research output data provided by the Research Excellence Framework (REF)

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