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Modelling of Palladium Implants for Prodrug Cancer Treatment

   School of Engineering & Physical Sciences

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  Dr A Ozel  No more applications being accepted  Competition Funded PhD Project (UK Students Only)

About the Project

About the Project

Most anti-cancer drugs have serious side effects, limiting their efficacy. These could be reduced by using a prodrug which circulates harmlessly until being activated at the tumour site. In this work, we will design/model Palladium-bearing polymers and study how the properties of the polymer govern Palladium encapsulation, and prodrug diffusion and conversion, which in turn will guide the design of clinically relevant implants. We will particularly focus on the kinetics of prodrug diffusion and conversion, combining experiments and mathematical modelling (physics-informed neural network model). 

We are looking for a candidate with experiences in the following areas:

•    Reaction kinetics and the stochastic diffusion-reaction transport equation

•    Data-driven mathematical modelling techniques (deep learning and neural network modelling)

•    Image processing methods

Entry requirements

As a formal qualification, all applicants must have or expect to have a 1st class MChem, MPhys, MEng, MSci or equivalent degree by Summer 2023. Selection will be based on academic excellence and research potential, and all short-listed applicants will be interviewed (in person or via Teams).

How to apply

Apply Online. When applying through the Heriot-Watt on-line system please ensure you provide the following information:

(a) in ‘Study Option’

You will need to select ‘Edinburgh’ and ‘Postgraduate Research’. ‘Programme’ presents you with a drop-down menu. Choose study option (Bio-engineering, Bio-sciences PhD/Chemistry PhD/Physics PhD/Electrical PhD/ Mechanical Engineering PhD etc.).

(b) in ‘Research Project Information’

You will be provided with a free text box for details of your research project. Enter Title of the project for which you are applying and also enter the supervisor’s name (Dr. Ali Ozel).

For questions about the application process, please contact EPS Post-Graduate Office ([Email Address Removed]).

For questions about the PhD project, please contact Dr. Ali Ozel ([Email Address Removed]).

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