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Modelling Receptor Uptake in Glucose Homeostasis

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  • Full or part time
    Prof M Chappell
  • Application Deadline
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  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

PhD in Interdisciplinary Biomedical Research

Fully funded studentship available for entry in September 2019

This Industrial Collaborative Award in Science and Engineering (iCASE) studentship is offered by Warwick’s MRC Funded Doctoral Training Partnership (DTP). This training program involves an exciting one-year MSc in Interdisciplinary Biomedical Research and then a three-year PhD project which is co-supervised by experts from both academia and industry. The student will benefit from a comprehensive training program that offers advanced workshops, career planning, transferable skills training and cohort learning events and conferences with ~ 50 other PhD students.

Title: Modelling Receptor Uptake in Glucose Homeostasis

University of Warwick and Industry Supervisors: Professor Michael Chappell (University of Warwick) and Dr Robert Willis (Sosei Heptares)

Project summary

The failure to regulate glucose levels in humans can lead to a range of diseases, most notably diabetes. This PhD project will utilise preclinical and clinical data from Sosei Heptares Therapeutics to develop mathematical models that describe the interaction of novel pharmaceutical agents with their cellular receptor(s) and predict their subsequent action on the pathways that regulate glucose homeostasis. Development of these models will provide a tool that can be used to interrogate how the various pathways interact, to select applicable patient populations and disease indicators and to help design clinical trials that enable the development of novel strategies for disease intervention.

Applicants should have a good undergraduate degree in mathematics, engineering, statistics or a related discipline.

Warwick’s MRC DTP Overview

MSc Course (Year One)
A one-year taught MSc in Interdisciplinary Biomedical Research, including taught modules (e.g. frontier techniques and research skills in biomedicine, principles and techniques in molecular biology, advanced microscopy and imaging, molecular modelling and physical biology of the cell) and two 11-week research projects.

PhD Project (Years Two – Four)
A three-year PhD project. Students will be supervised jointly by a Warwick Principal Investigator and an industry partner, and will undertake a minimum of three months’ placement with the industry partner.

If you are interested in joining our dynamic DTP community please apply at by Thursday 14 February 2019.

Interviews will take place on Monday 8 April 2019.

Funding Notes

Studentships covering full fees, consumables and annual stipend of £17,499 * are available. for full information.

Entry Requirements
A strong first degree (2i or above) or international equivalent in a relevant subject. Please see the website for further information about academic entry and residency requirements.

* to be confirmed.

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