About the Project
The Respiratory Microbiome Group seeks to understand the interactions between complex communities of bacteria, fungi and viruses with the human respiratory tract in both disease (acute infections and chronic lung disease) and in health or healthy ageing. The group is interdisciplinary and collaborates with immunologists and clinicians in order to understand how the microbiome influences human health.
This PhD project aims to characterise and model these interactions using a variety of methods including bacterial and tissue culture, 16S rRNA gene and metagenomic sequencing of respiratory specimens, in vitro models of the microbiota with macrophages and understanding the influence of treatments such as antibiotics and steroids on these interactions. The student will gain training in wide range of interdisciplinary techniques and join an inclusive and active research group.
We are seeking talented, motivated students with a passion for research in the human microbiome and respiratory disease to join the Respiratory Microbiome Group led by Dr Michael Cox https://www.birmingham.ac.uk/staff/profiles/microbiology-infection/cox-michael.aspx
Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.
Cardenas, PA, Cox, M, Willis-Owen, SAG, Moffatt, MF, Cookson, WOC & Cooper, P 2023, 'Delayed acquisition of airway commensals in antibiotic naive children and its relationship with wheezing in rural Ecuador', Frontiers in Allergy, vol. 4, 1214951. https://doi.org/10.3389/falgy.2023.1214951
Chotirmall, SH, Bogaert, D, Chalmers, JD, Cox, MJ, Hansbro, PM, Huang, YJ, Molyneaux, PL, O'Dwyer, DN, Pragman, AA, Rogers, GB, Segal, LN & Dickson, RP 2022, 'Therapeutic targeting of the respiratory microbiome', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 5, pp. 535-544. https://doi.org/10.1164/rccm.202112-2704PP
Cox, MJ, Loman, N, Bogaert, D & O'Grady, J 2020, 'Co-infections: potentially lethal and unexplored in COVID-19', The Lancet. Microbe, vol. 1, no. 1, pp. e11. https://doi.org/10.1016/S2666-5247(20)30009-4