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Modified nucleoside triphosphates with unnatural nucleobases for enzymatic synthesis of modified DNA

  • Full or part time
    Prof M Hocek
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The project will deal with the study and development of the chemical synthesis of diverse modified nucleoside triphosphates derived from d5SICS and dMMO2 nucleosides, which are used in the extension of the genetic alphabet. New derivatives bearing useful functional groups will be designed and synthesized aiming at the modification of DNA in the major groove. Substrate activity of these dNTPs with diverse DNA polymerases will be studied and they will be used for site-specific modification of DNA or in enzymatic synthesis of hypermodified DNA.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Seo, Y. J.; Malyshev, D. A.; Lavergne, T.; Ordoukhanian, P.; Romesberg, F. E. Site-specific Labeling of DNA and RNA Using an Efficiently Replicated and Transcribed Class of Unnatural Base Pairs. J. Am. Chem. Soc. 2011, 133, 19878–19888.

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