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Modular design and assembly of innovative biopolymer beads as drug delivery platform


Project Description

The FDA-approved polyhydroxybutyrate self-assembles in engineered bacteria and forms spherical beads of approximately 200 nm in diameter. Such beads composed of polymeric core and protein shell are of considerable interest as drug carrier platform as they provide payload for drugs and their surface can be engineered to targeted drug delivery. Synthetic biology will be applied to engineer these beads for proof-of-concept studies aiming at cancer treatment in a mouse model.

Funding Notes

About the Scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Rehm, B. H. A. et al., Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications. ACS Biomaterials Science & Engineering 2017, 3 (12), 3043-3057.

2. Rehm, B. H. A. et al., Multifunctional Inorganic-Binding Beads Self-Assembled Inside Engineered Bacteria. Bioconjugate Chemistry 2008, 19 (10), 2072-2080.

3. Hui, Y.; Wibowo, D.; Liu, Y.; Ran, R.; Wang, H.-F.; Seth, A.; Middelberg, A. P. J.; Zhao, C.-X., Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting. ACS Nano 2018, 12 (3), 2846-2857.

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