University of Exeter Featured PhD Programmes
University College London Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
Imperial College London Featured PhD Programmes
Centre for Genomic Regulation (CRG) Featured PhD Programmes

Modulation of cell fate decisions to define novel cancer therapies

  • Full or part time
  • Application Deadline
    Monday, January 06, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

PhD Start date: September 2020

Whether a cell dies or not has profound consequences on health. For instance, if programmed cell death (apoptosis) is not correctly executed in response to damage signals it can lead to cancer. Blocks in the apoptotic pathway may trigger a permanent arrest instead (senescence), which contributes to cancer through the secretion of cytokines and interleukins. Understanding these cell fate decisions is essential to ensure the process of cell death proceeds correctly and damaged and transformed cells are eliminated. This project will study the mechanism by which an apoptotic block contributes to senescence using both cell biology and structural biology techniques, in order to develop novel therapeutic strategies for cancer. This project will determine how key pathways can be modulated to selectively induce apoptosis instead of senescence, which has a strong clinical relevance, and to visualise for the first time the key multi-protein complexes that determine cell fate decisions by Cryo-electron microscopy.

Academic entry requirements:
UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

How to apply:
Standard application: https://le.ac.uk/study/research-degrees/funded-opportunities/cls-mcb-liscb-2020

Eligibility:
UK and EU candidates only

Funding Notes

Funding Source: College studentship
Funds will cover stipend (at Research Council rates)
University tuition fee waiver for 3 years

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.