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Modulation of Protein Function using Molecular Imprinting

   Faculties of Health & Life Sciences and Technology

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  Prof Nick Turner  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Molecularly Imprinted Polymers (MIPs) are simple, elegant biomimetics that incorporate binding sites bearing steric and chemical functionality complementary to a given target. They represent a generic, versatile, scalable, cost-effective approach to the creation of synthetic molecular receptors and have uses in separation sciences, purification, sensors and catalysis.

DMU is offering a fully-funded 3-year PhD scholarship in this area, commencing 3rd October 2022. Under the supervision of Professor Nick Turner (EPSRC Established Career Fellow), this will seek to broaden horizons towards development of imprinted materials and their application in sensor design and are in collaboration with several industrial/academic partners. You will form part of a growing team at DMU looking at pushing the capabilities of molecular imprinting techniques at the biological interface.

Modulation of Protein Function using Molecular Imprinting

This project will focus on the development of nanoscale molecularly imprinted polymers capable of modulating the function of proteins, creating novel enzymatic inhibitors. Expected techniques used over the project will include a range of synthetic polymer chemistry methods; chromatographic and spectroscopic techniques (including circular dichroism); mass spectrometry; NMR; surface plasmon resonance; and enzymatic assaying.

Financial support and application details

The stipends are set to the current UKRI rate, and include fee waivers for home (UK) students. International students’ fees are subject to discussion with the university, on interview.

Applicants must:

· Possess a minimum of an Upper Second Class (2:1) or equivalent Honours degree in Chemistry, Biochemistry, Chemical Engineering, or other relevant subject.

· Demonstrate competence in the use of the English language. Please see section 5b here for further details on meeting our English language entry criteria.

· Ideally, have experience with polymer chemistry and/or structural biology; working with protein samples; an interest in chemistry at the biological interface; and/or interest in the structure of proteins.

How to apply

Candidates should submit a full application through the DMU PGR Admissions Portal. Information on how to apply can be found here. Alongside the university application your application should include:

·  A full CV which clearly indicates your Undergraduate (and Masters, if applicable) degree results and transcripts of modules completed during your studies. If degree results are provisional/expected, then please indicate your expected grade.

·  A cover letter indicating:

o  why you are interested in this area of study;

o  an explanation why you have the desired qualities and experience for the proposed study.

Informal discussions on this project should be directed to Professor Nick Turner by email ([Email Address Removed]) or by phone (0116 207 8416). 

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