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Modulatory functions of microglia on medium spiny neuron function and degeneration in stem cell models of Huntington’ Disease


Project Description

Studentship Summary
This studentship is part of a SCTN-Training network of 14 studentships, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813851. ASCTN-Training is addressing existing gaps within Human Stem Cell-based Neuronal disorders (NDs) Modelling (NDM) for research to develop new medicines for the treatment of neurological disorders (e.g. Parkinson´s (PD), Huntington´s (HD) and Demyelination’s (DM) diseases), which occur as a result of acute or progressive loss of cells, glial or neuronal, and structures and function in the brain. ASCTN-Training sets out with the ambition to educate and train students within and across different scientific disciplines: biotechnology (Human Pluripotent Stem Cells (hPSCs) neuronal and glial differentiation using brain-on-chip technology and microfluidics, 3D tissue engineering/cerebral organoids and nanoengineering of culture conditions), molecular biology (Ex vivo gene expression, Direct cellular reprograming, mouse genetic modification, single cell analysis), in vivo mouse manipulations (Animal models of NDs, stem cell transplants into the brain, scaffold implantation, direct tissue engineering).
This project will use Huntington’s disease induced pluripotent stem cells and develop novel strategies to investigate the interactions between microglia, neurons and astrocyte and neuroinflammatory mechanism of disease.
Principal investigator: Nick Allen and Anne Rosser (; )


Requirements:
• A scientific university degree with exceptional academic performances (for EU qualification equivalences see http://www.cardiff.ac.uk/study/postgraduate/applying/admissions-criteria)
• Less than 4 years full time equivalent research experience and not yet been awarded a doctoral degree (PhD)
• Having resided less than 12 months in the UK in the 3 years prior to selection
• Excellent communication and organization skills
• Fluent in spoken and written English
• Excellent writing and presentation skills
Flexibility and ability to work in a team environment
• Availability to travel nationally and internationally two to three times a year

Funding Notes

Salary and appointment terms
The salary will be in line with the European Commission rules for Marie Skłodowska-Curie grant holders (Early-Stage Researchers, European Training Network).
The successful candidate will be registered for the PhD degree at Cardiff University (View Website) and will be expected to (i) submit a doctoral thesis within three years and (ii) carry out research and training at one or more European project partners (e.g. Karolinska Institute, San Raffaele Hospital, University of Cardiff, University of Barcelona, Technische Universität Dresden, Universidad Autónoma de Madrid).
For more information please see:
View Website.

Related Subjects

How good is research at Cardiff University in Biological Sciences?

FTE Category A staff submitted: 54.70

Research output data provided by the Research Excellence Framework (REF)

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