Molecular basis of cellular organisation

Dr M Dodding
Applications accepted all year round
Self-Funded PhD Students Only

School of Biochemistry, University of Bristol

About This PhD Project

Project Description
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References

Project Description

Research in our lab aims to understand the molecular mechanisms and signaling pathways that control the distribution and dynamics of subcellular components, focusing on structure, function, molecular mechanism and regulation of the key biomolecular machines regulate cellular organization including cytoskeletal motor proteins. We seek to apply that knowledge to develop novel chemical tools to acutely manipulate these systems to obtain new insights. We take a multi-disciplinary approach that combines advanced cell imaging with cell biology, biophysics and structural approaches to define the molecular basis of these dynamic processes. We have a number of projects available and informal enquiries are encouraged. See https://www.ncbi.nlm.nih.gov/pubmed/?term=Dodding+MP for lab publications.

References

1: Randall TS, Yip YY, Wallock-Richards DJ, Pfisterer K, Sanger A, Ficek W,
Steiner RA, Beavil AJ, Parsons M, Dodding MP. A small-molecule activator of
kinesin-1 drives remodeling of the microtubule network. Proc Natl Acad Sci U S A.
2017 Dec 26;114(52):13738-13743. doi: 10.1073/pnas.1715115115. Epub 2017 Dec 11.
PubMed PMID: 29229862; PubMed Central PMCID: PMC5748212.

2: Starling GP, Yip YY, Sanger A, Morton PE, Eden ER, Dodding MP. Folliculin
directs the formation of a Rab34-RILP complex to control the nutrient-dependent
dynamic distribution of lysosomes. EMBO Rep. 2016 Jun;17(6):823-41. doi:
10.15252/embr.201541382. Epub 2016 Apr 13. PubMed PMID: 27113757; PubMed Central
PMCID: PMC4893818.

3: Yip YY, Pernigo S, Sanger A, Xu M, Parsons M, Steiner RA, Dodding MP. The
light chains of kinesin-1 are autoinhibited. Proc Natl Acad Sci U S A. 2016 Mar
1;113(9):2418-23. doi: 10.1073/pnas.1520817113. Epub 2016 Feb 16. PubMed PMID:
26884162; PubMed Central PMCID: PMC4780624.

4: Pernigo S, Lamprecht A, Steiner RA, Dodding MP. Structural basis for
kinesin-1:cargo recognition. Science. 2013 Apr 19;340(6130):356-9. doi:
10.1126/science.1234264. Epub 2013 Mar 21. PubMed PMID: 23519214; PubMed Central
PMCID: PMC3693442.

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Molecular basis of cellular organisation

University of Bristol

School of Biochemistry