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Molecular Basis of Interfacial Interactions in Crystalline Organic Materials

  • Full or part time
  • Application Deadline
    Friday, January 03, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Crystallization of organic compounds is a separation and purification technique widely used across industrial sectors: pharmaceuticals, agrochemicals, foods, healthcare and many formulated household products contain crystalline particulate components. Their relevant physical properties, such as stability and resilience, texture, solubility and dissolution rates, are related to interlinked multi-scale properties. Many of these are readily determined, such as composition, size distribution, morphology and internal crystal structure (including polymorphism) of particles. However, surface and interfacial properties, which are widely recognised to have critical influence on downstream processing, are not. Molecular level variations in surface properties determine critical macroscopic observables (e.g., wettability, polarity, surface chemistry) and impact virtually every step of manufacturing (blending, milling, granulation, tableting) and ultimately product performance (e.g. stability, powder caking, dissolution profiles). Poor control of surface properties is believed to be one of the most common manufacturing and product failure mode across all the relevant industrial sectors.

This project is available as one of five PhD studentships with the Bragg Centre to tackle fundamental and applied problems to create new and improve existing materials. These will address fundamental and applied problems across design, characterisation, fabrication and modelling. The Centre comprises around 150 members from over ten Schools and has had continued investment in excellent facilities and infrastructure, including a new building opening in 2020, to ensure that our staff and students benefit from state-of-the-art, high quality equipment and laboratories. We are a founding partner of the Henry Royce Institute, the UK’s Institute for Advanced Materials.

Funding Notes

Funding is available from the Bragg Centre for Materials Research for 3.5 years and covers the cost of academic fees at the UK/EU rate (currently £4,500 per year for 2019/20) and provides a stipend at EPSRC rates (currently £15,009 per year for 2019/20).

How good is research at University of Leeds in Agriculture, Veterinary and Food Science?

FTE Category A staff submitted: 14.40

Research output data provided by the Research Excellence Framework (REF)

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