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Molecular Design for Drug Discovery


   Department of Pure and Applied Chemistry

  , Dr Fraser Scott  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Background

Drug resistance is a growing concern for the future of effective medicine. For this reason, new paradigms in drug design are actively being sought. This PhD project will take a biophysical approach to investigating molecular recognition processes between potential drug molecules and their nucleic acid targets. It will involve NMR spectroscopy for data collection and in silico modelling alongside associated analytical chemistry techniques that will lead to a fuller understanding of the subtle factors which play their role in these molecular recognition processes. Scope exists for developing new concepts in drug design as part of this research drive alongside new experimental methods to better explore the complex data analysis problem.

 The student will join a small team of analytical and synthetic chemists within an NMR laboratory setting. They will become expert in the application of NMR spectroscopy and in silico methods to nucleic acid/drug recognition systems. World-class training will be provided to develop the student into an independent professional researcher through Strathclyde’s extensive Researcher Development Programme.

 Eligibility

Candidates should hold or expect to hold a first or upper second class (Bachelors or Masters) degree in a relevant discipline (chemistry, biophysics or related areas).

 Application procedure

Applicants should submit a CV by email to:

 Key words:

NMR spectroscopy, molecular modelling, in silico, molecular recognition, drug design, nucleic acids


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