Continue with FacebookLooking to list your PhD opportunities? Log in here.
Prof N J Gay
Applications accepted all year round
Competition Funded PhD Project (Students Worldwide)
About the Project
Our research aims to elucidate the molecular and cellular regulation of innate immune signal transduction in the context of infectious, inflammatory and autoimmune disease. We focus on the Toll-like receptors that respond to pathogen associated molecules such as lipopolysaccharide and non-self nucleic acids. A second strand of our research is the functional and evolutionary inter-relationships in the ontogeny of the nervous and immune systems. We focus on the function of Toll receptors in invertebrate neurogenesis and the role of signaling by Toll-like receptors (TLRs) and LRRK2 in vertebrate microglia for the initiation and progression of neurodegenerative diseases, especially Parkinson’s. We published high impact papers showing that in Drosophila Toll receptors fulfill the function of neurotrophins in the insect nervous system. Our future research aims are to use cutting edge techniques in single molecule imaging of live cells, biophysics, structural and cell biology to elucidate the kinetics, dynamics and cooperativity of inflammatory signaling.
References
1. Latty, S. L., Sakai, J., Hopkins, L., Verstak, B., Paramo, T., Berglund, N. A., Cammorota, E., Cicuta, P., Gay, N. J., Bond, P. J., Klenerman, D., and Bryant, C. E. (2018) Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub. Elife 7, 31377.
2. Pizzuto, M. Lonez, C., Gangloff, M. Tourlomousis, P., Pelegrín, P., Ruysschaert, J-M., Gay N.J. and Bryant, C.E. (2019) Saturation of cardiolipin acyl chains flips Toll-like receptor-4 activity from antagonist to agonist. Cell Mol Life Sci.76, 3679-3680.
3. Levy, D., Tourlomousis, P., Hopkins, L., Symmons, M.F., Bryant, C.E. (2019). Parkinson’s disease associated kinase LRRK2 regulates the expression of genes required for cell adhesion, motility and chemotaxis in activated macrophages.in press. J Biol Chem
4. Gay, N. J. (2019) Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors. BMC Biol 17, 15.
5. Sardinha-Silva, A., Pinzan, C., Mendonça-Natividade, F.C., Lopes, C. D., Costa, D. l., Jacot, D., Fernandes, F.F., Zorzetto-Fernandes, A., Gay, N.J., Sher, A., Jankovic, D., Soldati-Favre, D., Grigg, M.E., Roque-Barreira, M.C. (2019) The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming. PLoS Path 15, e1007871.
6. Moncrieffe, M., Bollschweiler D., Li, B., Penczek, P.A. Hopkins, L., Bryant, C. E. David Klenerman, D and Gay, N.J. (2019) MyD88 death domain oligomerisation determines Myddosome architecture: Implications for TLR signalling. Structure, in press.
7. Lauenstein, J.U., Udgata, A., Bartram, A., De Sutter, D., Fisher, D., Halabi, S., Eyckerman, S. and Gay N.J. (2019) Phosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) facilitates recruitment of multiple SH2/SH3 proteins including Grb2. J Biol Chem jbc.RA119.009931. doi:10.1074/jbc.RA119.009931.
2. Pizzuto, M. Lonez, C., Gangloff, M. Tourlomousis, P., Pelegrín, P., Ruysschaert, J-M., Gay N.J. and Bryant, C.E. (2019) Saturation of cardiolipin acyl chains flips Toll-like receptor-4 activity from antagonist to agonist. Cell Mol Life Sci.76, 3679-3680.
3. Levy, D., Tourlomousis, P., Hopkins, L., Symmons, M.F., Bryant, C.E. (2019). Parkinson’s disease associated kinase LRRK2 regulates the expression of genes required for cell adhesion, motility and chemotaxis in activated macrophages.in press. J Biol Chem
4. Gay, N. J. (2019) Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors. BMC Biol 17, 15.
5. Sardinha-Silva, A., Pinzan, C., Mendonça-Natividade, F.C., Lopes, C. D., Costa, D. l., Jacot, D., Fernandes, F.F., Zorzetto-Fernandes, A., Gay, N.J., Sher, A., Jankovic, D., Soldati-Favre, D., Grigg, M.E., Roque-Barreira, M.C. (2019) The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming. PLoS Path 15, e1007871.
6. Moncrieffe, M., Bollschweiler D., Li, B., Penczek, P.A. Hopkins, L., Bryant, C. E. David Klenerman, D and Gay, N.J. (2019) MyD88 death domain oligomerisation determines Myddosome architecture: Implications for TLR signalling. Structure, in press.
7. Lauenstein, J.U., Udgata, A., Bartram, A., De Sutter, D., Fisher, D., Halabi, S., Eyckerman, S. and Gay N.J. (2019) Phosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) facilitates recruitment of multiple SH2/SH3 proteins including Grb2. J Biol Chem jbc.RA119.009931. doi:10.1074/jbc.RA119.009931.
How good is research at University of Cambridge in Biological Sciences?
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universitiesEmail Now
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
Why not add a message here
* required field
The information you submit to University of Cambridge will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search suggestions
Based on your current searches we recommend the following search filters.
Check out our other PhDs in Cambridge, United Kingdom
Check out our other PhDs in United Kingdom
Start a New search with our database of over 4,000 PhDs
PhD suggestions
Based on your current search criteria we thought you might be interested in these.
Understanding the molecular mechanism of a novel innate bacterial defence system and its synergy with CRISPR-Cas
University of Bristol
Investigate the molecular mechanism controlling FEME (Fast Endophilin Mediated Endocytosis) in directed cancer cell migration using CRISPR, biochemistry, and advanced microscopy methods.
King’s College London
The mechanism of regulation of protein synthesis via eIF2 molecular complexes
The University of Manchester