Prof Bibek Gooptu, Dr I Campeotto
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
This project integrates structural and cell biology to better understand and treat a major, but under-recognised, disease process. Approximately 45% of deaths in the developed world result from fibrosis (scarring) of vital organs: more people are living longer with chronic disease, and we lack highly effective drugs to treat fibrosis. The project will use biophysics (ITC), structural (X-ray crystallography, NMR spectroscopy), and cellular studies to improve our understanding of important pro-fibrotic mechanisms and help develop drugs to target them. Dr Campeotto has optimised methods to make and purify the important pro-fibrotic protein NOX4. Prof Gooptu’s group have recently identified a novel molecular pathway mediating epithelial responses to lung injury triggers that worsen (exacerbate) fibrosis. The project will focus upon NOX4 and 2 key exacerbation pathway components, all validated as attractive therapeutic targets in cells and in vivo. We will test the conclusions from structural studies in our cell models of disease.
Entry requirements
https://www2.le.ac.uk/research-degrees/funding/life-sciences/LISCB_MCBadvert2019.pdf
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The University of Leicester English language requirements apply where applicable.
How to apply
You should submit your application using our online application system:
https://www2.le.ac.uk/research-degrees/phd/applyphd
Apply for a PhD in Molecular and Cell Biology for September 2019
In the funding section of the application please indicate you wish to be considered for a LISCB/MCB 2019 Studentship
In the Proposal section of the online application please list the names of the supervisor/projects you want to be considered for. (You do not need to submit a separate application for each project).
Project / Funding Enquiries: [Email Address Removed]
Application enquiries to [Email Address Removed]
Closing date for applications 6 January 2019
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