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Molecular mechanisms of how human DNA damage response controls the pathway choice of DNA repair

Project Description

Life is full of decisions! One of the biggest decisions cells need to make is how to deal with DNA damage. We study DNA-double strand breaks (DSBs), which are the most toxic type of DNA damage in cells. We want to understand how different proteins assemble at the sites of DNA damage, and how this allows cells to decide between different specific repair pathways. To achieve this goal, we combine cutting-edge techniques such as cryo-EM to visualize their structures and characterize their functions. This study will expand our fundamental understanding of pathway choice in DNA repair at a molecular level in healthy cells, but the long-term applications of this knowledge will be to understand how these decisions go wrong in cancer cells. Ultimately, we want to exploit these differences to develop drugs that can kill cancer cells specifically.
We are looking for an ambitious and enthusiastic student to join our research group. Successful PhD candidate will become an expert in protein purification, complex reconstitution, biochemical and biophysical characterisations and structural determination by cryo-EM.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2019:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency in order to receive full studentship

Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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Related Subjects

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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