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Molecular mechanisms of microglia-driven neurodegeneration in human tauopathies

   Department of Clinical Neurosciences

   Thursday, December 01, 2022  Competition Funded PhD Project (Students Worldwide)

About the Project

Neuroinflammation is associated with many neurodegenerative disorders. In experimental animals of tauopathies, microglia were shown to play a role in tau propagation and synapse loss, however the molecular and cellular processes driving tau accumulation and neurodegeneration in the context of human disease remain poorly understood. We are investigating the role of microglial responses in human tauopathies with progressive supranuclear palsy (PSP) as the demonstrator condition. Using advanced spatial biology and high-resolution imaging techniques we will characterise the molecular signatures of microglia and their interactions with tau aggregates and other cell types. This project relies on the large collection of well-characterised PSP brains in the Cambridge Brain Bank, enabling to study microglia in a large range of disease severities. With this strategy we anticipate to better understand the role of microglia in PSP and tauopathies, and hence, to guide the design of novel neuroimmune therapies and new disease biomarkers.  

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