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  Molecular mechanisms of TAR DNA-binding protein 43 (TDP-43) proteinopathies


   School of Chemistry and Molecular Bioscience

  Prof Lezanne Ooi  Monday, July 29, 2024  Funded PhD Project (Students Worldwide)

About the Project

PhD Start Date: January/February 2025 at the University of Wollongong

Application form will open on 24th May 2024 (University of Wollongong, Graduate Research School) and close on Monday 31st July 2024 at 23:59 AEDT.

Funding Package:

The funding package for this studentship scheme is as follows:

·       Full tuition fee waiver p.a.

·       Stipend at Research Training Program rates (circa $34,000 p.a.)

·       The stipend is funded for 3.5 years. The candidate will spend 24 months at University of Wollongong, Australia, followed by 12 months at University of Surrey, UK, before returning to UOW for the last 6 months.

Programme Details

Fields of research: 

Neuroscience, Quantum Biotechnology, Chemistry and Molecular Bioscience

Host Department/School - University of Wollongong, Australia and Affiliations:

School of Chemistry and Molecular Bioscience, Molecular Horizons

Department/School - University of Surrey, UK and Affiliations:

School of Biosciences, Leverhulme Quantum Biology Doctoral Training Centre

Supervisory team and affiliations

The PhD candidate will be supervised by Prof Lezanne Ooi (neuroscientist, UOW) and Prof Haibo Yu (computational biophysicist, UOW), Dr Youngchan Kim (quantum biologist, UOS) and Prof Jim Al-Khalili (theoretical physicist, UOS). The candidate will be affiliated with the ARC Centre of Excellence in Quantum Biotechnology (QUBIC), of which Prof Ooi is leading the ‘Neural Imaging Theme’ https://www.qubic.au/ . At UOS, the candidate will be integrated into the Leverhulme Quantum Biology Doctoral Training Centre (QB-DTC), of which Prof Al-Khalili is co-director https://www.surrey.ac.uk/leverhulme-quantum-biology-doctoral-training-centre .

Project: ‘Harnessing novel quantum tools for neural imaging in neurodegenerative disease’

TAR DNA-binding protein 43 (TDP-43) is vital in controlling mRNA and protein levels in cells and is dysreglated in neurodegenerative diseases, such as motor neuron disease and dementia.  A multi-disciplinary approach, harnessing novel quantum tools, will be used to study the molecular mechanisms underlying TDP-43-diseases, capitalising on unique expertise in quantum biotechnology at UOW and UOS. Biochemical and computational studies will be used to study the factors affecting TDP-43 misfolding and aggregation.

The PhD candidate will gain expertise in modern experimental and computational biophysical techniques and will have the unique opportunity to be trained in the emerging high impact field of quantum biotechnology.

Please contact the project supervisors for additional information (University of Wollongong, Australia): Professor Lezanne Ooi ; Prof Haibo Yu ; (University of Surrey, UK) Dr Youngchan Kim ; Prof Jim Al-Khalili

Please find information about the scholarship here:

https://www.uow.edu.au/research-and-innovation/graduate-research/scholarships/#/UOW%20%2F%20UoS%20Joint%20Dual%20Degree%20PhD%20Scholarship%20-%20Molecular%20mechanisms%20of%20TAR%20DNA-binding%20protein%2043%20(TDP-43)%20proteinopathies

Please find the application link here:

https://uow.au1.qualtrics.com/jfe/form/SV_5u5BDRBEt8AB1kO

Biological Sciences (4) Engineering (12) Physics (29)

Funding Notes

University of Wollongong Australia / University of Surrey UK Joint-Dual Degree PhD Scholarship. Applications via University of Wollongong website


Register your interest for this project


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