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Molecular microbiology of Mycobacterium tuberculosis and related Actinobacteria

   Department of Respiratory Sciences

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  Dr H O'Hare  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

M. tuberculosis causes tuberculosis, causing 1.5 million deaths per year. Other members of the Actinobacteria include the important human pathogens M. avium and M. abscessus, animal pathogens, and non-pathogenic bacteria used in industry (Corynebacterium glutamicum), and for antibiotic production and drug discovery (Streptomyces spp. and others).

The aim of the project is to increase understanding of basic bacterial physiology of the Actinobacteria and/or to make advances in applied bacteriology (technology or drug discovery) by hypothesis driven research using biochemical, genetic or microbiological approaches.

This would lead to a PhD in Biochemistry or Microbiology.


An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria https://pubmed.ncbi.nlm.nih.gov/30065086/
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis https://pubmed.ncbi.nlm.nih.gov/28545104/
Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division https://pubmed.ncbi.nlm.nih.gov/31171861/
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