Molecular modelling of proteins relevant to SARS-Cov2

Coventry University (CU) is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship

While human ACE2 is the most important human protein involved in SARS-Cov2 infection, we will model the role of other potential human viral co-receptors, include B0AT1, TMPRSS2 and integrins. Many additional proteins, e.g. protein 7a, are encoded in the viral genome. The aetiology of covid-19 complications such as acute respiratory distress syndrome (ARDS) involves an over-reaction of the immune system through cytokines such as IL6.

We will investigate all these proteins as potential drug target using computational chemistry; for some the structure is known, for others we require comparative modelling. We can bring a unique approach to comparative modelling based on highly accurate sequence alignment methods that work in the twilight zone. Drug repurposing strategies will be used, since existing drugs have already passed a cascade of safety tests. While other groups will have docked the known FDA approved drugs to the main binding site of these proteins, we propose to identify alternative (allosteric) binding sites and dock the approved drugs to those sites since allosteric binding sites often confer advantages over targeting the main binding site.

We will develop our unique approach to identifying allosteric binding sites based on sequence conservation, protein topology and probe interaction energies.
Training and Development
The successful candidate will receive comprehensive research training including technical, personal and professional skills.

All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.
Entry criteria for applicants to PHD
• A minimum of a 2:1 first degree in a relevant discipline/subject area (physical sciences/life sciences/mathematics) with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average.
PLUS
the potential to engage in innovative research and to complete the PhD within a 3.5 years
• a minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component)

For further details see: https://www.coventry.ac.uk/research/research-students/making-an-application/
How to apply
To find out more about the project please contact Prof Chris Reynolds, [Email Address Removed].

To apply on line please visit:
https://pgrplus.coventry.ac.uk/studentships/hls-molecular-modelling-of-proteins-relevant-to-sars-cov2

All applications require full supporting documentation, a covering letter, plus an up to 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.