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Molecular Probes for Lysosomal Accumulation, Release and Environmental Sensing


   Department of Pure and Applied Chemistry

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  Prof Nick Tomkinson  Applications accepted all year round  Funded PhD Project (European/UK Students Only)

About the Project

Lysosomes are membrane bound organelles characterised by a low pH, which contain hydrolytic enzymes that function as part of the cellular recycling system. The low pH associated with these organelles provides a unique opportunity for accumulation, release, and sensing using small molecules, permitting an understanding of this chemical environment and its relationship to disease. We will design, synthesise, and monitor small molecules that are able to examine each of these areas using bioinformatics to process and interpret the imaging data generated.

Key Words: chemical biology, synthesis, organic, probe, Raman Spectroscopy, bioinformatics


References

A New Class of Ratiometric Small Molecule Intracellular pH Sensors for Raman Microscopy. Wilson, Liam T.; Tipping, William J.; Jamieson, Lauren E.; Wetherill, Corinna; Henley, Zoë; Faulds, Karen; Graham, Duncan; Mackay, Simon P.; Tomkinson, Nicholas C. O. Analyst, 2020, 145, 5289–5298.
Ratiometric sensing of fluoride ions using Raman spectroscopy. Tipping, William, J.; Wilson, Liam T; Balieso, Sonja; Tomkinson, Nicholas, C. O.; Faulds, Karen, Graham, Duncan. Chem. Commun. 2020, 56, 14463–14466.
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