Molecular targets of analgesic natural compounds in the sensory system

How do mammals detect touch, temperature, and pain? How does the body defensively increase sensitivity of injured tissues, making otherwise innocuous movements feel painful? And how, as an inevitable consequence of aging, does this process go wrong over time, creating burdensome chronic pain? To answer these questions, we must look at sensory nerves, which supply our body with the ability to detect information about the environment. They do so via protein molecules called receptors, tuned to detect specific types of stimuli.

Our team is interested in uncovering and characterizing these receptors, with the aim of finding new targets for better, safer analgesic therapy. This project will take advantage of naturally occurring compounds that modulate the sense of touch and pain, aiming to identify their molecular targets. We will use state-of-the-art technology in functional genomics, fluorescent imaging and electrophysiology to identify and study such proteins.

Eligibility: 

You should hold a first degree equivalent to at least a UK upper-second class honours degree or a MSc degree in a relevant subject.

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The Faculty of Biological Sciences minimum requirements in IELTS and TOEFL tests are:

• British Council IELTS - score of 6.0 overall, with no element less than 5.5
• TOEFL iBT - overall score of 87 with the listening and reading element no less than 20, writing element no less than 21 and the speaking element no less than 22.

How to apply:

To apply for this project applicants should complete an online application form and attach the following documentation to support their application. 

• a full academic CV
• degree certificate and transcripts of marks
• Evidence that you meet the University's minimum English language requirements (if applicable).

To help us identify that you are applying for this studentship please ensure you provide the following information on your application form;

• Select PhD in Biological Sciences as your programme of study
• When asked for source of funding please make it clear that you are applying for a "White Rose BBSRC DTP Studentship"
• Give the full project title and name the supervisors listed in this advert. You can be considered for up to 3 projects in total.

If you have any further queries regarding this opportunity, please contact [Email Address Removed]