Monitoring bacterial metabolism using advanced metabolomics methods

The University of Nottingham seeks an enthusiastic PhD candidate to work on an exciting multi-disciplinary project that brings together the techniques of synthetic biology, analytical science and systems biology.

This 4-year PhD project is part of a University-funded Doctoral Training Programme in Synthetic Biology and associated with Nottingham’s new BBSRC/EPSRC Synthetic Biology Research Centre. Students will benefit from a training in a range of widely applicable techniques, including through specialist workshops, lectures and seminars, as well as participation in Nottingham’s yearly BBSRC DTP Spring School event. This studentship will be based in the School of Pharmacy with collaborative links to the School of Life Sciences and the School of Mathematical Sciences.

The project will focus on understanding bacterial cell metabolism under specific growth conditions and predicting metabolic phenotypes after genetic and/or environmental perturbations. Experimental work will involve the development and application of metabolic flux analysis based on LC-MS based metabolomics data. Quantitative models will built based on generated data in order to monitor the metabolism of a variety of bacterial species. The overall aim is to integrate metabolomics data into the systematic development of metabolic engineering strategies.

For further information about this studentship, please contact Dr Dong-Hyun Kim ([Email Address Removed]).

To apply on-line, please access: http://www.nottingham.ac.uk/pgstudy/how-to-apply/apply-online.aspx