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MPhil - Design and development of a novel Multi-layered antimicrobial catheter device


   Cardiff School of Pharmacy and Pharmaceutical Sciences

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  Dr P Prokopovich, Dr F Pertusati  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

This is for a one year MPhil starting on the 1st April 2022

The project aims to develop a novel catheter device releasing non-antibiotic based antimicrobial agents providing prophylaxis and treatment of urinary catheter associated infection (UCAI). To offer alternative biomaterial substrates for urinary catheters and to enhance the company’s product portfolio.

Microbial infections are a serious risk associated with any type of medical device; specifically urinary catheter associated infection is one of the most common infections acquired by patients in health care facilities. This concern is also aggravated by the increasing number of microorganisms acquiring genetic resistance to antibiotics, and the ability of many pathogens to form biofilms, leading to phenotypic resistance.

The development of antimicrobial therapies or prophylactic treatments not based on antibiotics is of particular interest and extremely urgent. Our project proposes to expand the applicability of already widely used antimicrobial compounds to urinary catheters through the specific coating development into catheter materials. This approach will allow the release of antimicrobial agents in controlled manner for a prolonged time providing prophylaxis and treatment from the UCAI. The project will combine the expertise of the Uroemerge Ltd, North Wales Clinical Research Centre and Cardiff University to develop novel catheter devices with anti-biofilm forming and antimicrobial properties alongside developing new alternative support materials for catheters with superior properties.

The successful student will get is a unique opportunity to collaborate and network with team members across two disciplines (Biomedical Engineering and Pharmacy).The student will learn a variety of skills: biomaterial and polymer chemistry, medical devices modification methods, coating techniques, polymer and coating characterisation techniques (such as FTIR, XPS, SEM, GPC, NMR techniques).

These techniques can be employed in a wide range of applications in chemistry, biological sciences, pharmacy and bioengineering. Therefore, the student will be able to transfer the acquired knowledge in different application facilitating his/her employment prospects.

Also the student will have a unique opportunity to work in industrial and clinical settings with Uroemerge and North Wales Clinical Research Centre, the student will gain vital commercial exposure and learn other useful skills for the future such as budget management skills and time management skills, develop leadership, communication and presentation skills. Both Uroemerge and North Wales Clinical Research Centre operate in a friendly, professional multicultural environment, they used to host placement students and supervise MPhil/PhD students in the past. The student will have a chance to work with people from different departments in these organisations: marketing teams, R&D and sales teams, Directors, regulators and customers. This way the student will develop and maximise communication effectiveness to specific audience.

Deadline for applications is 28th February 2022. We reserve the right to close applications early, if sufficient applications are received.

Applicants should apply to the Master of Philosophy Pharmacy with a start date of April 2022

In the research proposal section of your application, please specify the project title and supervisors of this project and copy the project description in the text box provided. In the funding section, please select 'I will be applying for a scholarship/grant' and specify that you are applying for advertised funding from KESS2 East

To apply - https://www.cardiff.ac.uk/study/postgraduate/research/programmes/programme/pharmacy


Funding Notes

To be eligible for the KESS2 funding, the successful candidate will need to be resident in the East Wales region at application for the scholarship and at enrolment with the University – A map of eligible areas is available here https://www.cardiff.ac.uk/__data/assets/pdf_file/0009/519273/Structural-Fund-regions-in-Wales-map.pdf for further details please email [[Email Address Removed]]
Please be aware that applicants must be UK residents. This funding cannot be used to apply for a student visa if you are an EU or international student.
Student stipend: £11,586 pa. In addition, there is travel and conference funding
For more information about KESS https://www.cardiff.ac.uk/business/develop-your-workforce/kess
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