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(MRC CASE) Analysis of Advanced Motion Kinetics and Kinematics, Correlated with Proteomic Approach to Biological Assessment of the Joint to Develop Optimised Personalised Knee Arthroplasty Surgery and Rehabilitation

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  • Full or part time
    Ms L Biant
    Prof T Freemont
    Dr C Milner
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

This project runs at the interface of biomedical engineering, cell biology and clinical orthopaedic surgery. It is a directly translatable project that allows the student to develop skills applicable to a variety of disciplines and also experience with patient interaction.
The student will analyse the gait of patients using advanced motion capture technology, before and after knee replacement surgery and quantify knee range of motion, muscle strength, stability and gait kinematics. The student would primarily be assessing and quantifying the biomechanics of the individual patient and how the extent of disease and muscle weakness affects their movement and ability to undertake activities of daily living. The student would look specifically at the frontal plane kinematics and change in joint line and tibial inclination of the knee when the surgery is done with using personalised kinematic alignment techniques and mechanical alignment techniques.
The biological milieu of the joint is important to gait and function. A proteomics approach to analysis of synovial fluid obtained at the knee replacement surgery will endeavour to correlate, for the first time, the biological and biomechanical objective measurements of patients with osteoarthritis of the knee, to personalise and improve their treatment and rehabilitation. The proteomics aspect of the study will further our understanding of how the biological environment affects function and builds on work at the Stoller Biomarker Discovery Centre, University of Manchester.
The project partners Medacta are at the cutting edge of biomedical engineering for patient benefit, and have developed inhouse 3D printing of bespoke personalised instruments and implants from 3DCT planning of surgery. The student will interact with the international bioengineering team at Medacta and learn the processes of invention to testing, licensing and commercialisation. Medacta has offered the successful student a paid internship of 6 months duration at the end of their project in addition to the placements during the studentship

Entry Requirements
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This is a CASE studentship in partnership with Medacta UK and will be funded under the MRC Doctoral Training Programme. If you are interested in this project, please make direct contact with the Supervisor to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found here

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.


Most recent 5 papers:

1. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. Duckworth AD, McQueen MM, Tuck CE, Tobias JH, Wilkinson JM, Biant LC, Pulford EC, Aldridge S, Edwards C, Roberts CP, Ramachandran M, McAndrew AR, Cheng KC, Johnston P, Shah NH, Mathew P, Harvie J, Hanusch BC, Harkess R, Rodriguez A, Murray GD, Ralston SH. J Bone Miner Res. 2019 [Epub ahead of print]

2. Current Surgical Options for the Treatment of Symptomatic Articular Cartilage Lesions of the Knee LC Biant MJ McNicholas J Orth and Trauma 2019 (Epub ahead of print)

3. Highly compressive and stretchable poly(ethylene glycol) based hydrogels synthesised using pH-responsive nanogels without free-radical chemistry.
Nguyen NT, Milani AH, Jennings J, Adlam DJ, Freemont AJ, Hoyland JA, Saunders BR
Nanoscale 2019 23:11(16);7921-7930

4. The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis
Hand LE, Dickson SH, Freemont AJ, Ray DW, Gibbs JE. Arthritis Res Ther 2019 6:21(1);5

5. Gait Variability and Motor Control in Patients with Knee Osteoarthritis as Measured by the Uncontrolled Maniforld Technique GF Tawy P Rowe LC Biant Gait Posture 2018 (59);272-77

Most relevant papers:

6. Synovial Fluid Analysis Anthony J Freemont and Eng Abdellatif Rheumatology 6th Edition 2015 Volume 1 p237-241

7. Functional outcome of the Medacta GMK-Sphere total knee arthroplasty as quantified by a clinical motion capture system. Tawy GF, Simons MR, Rowe PJ, Biant LC The BioMedEng18 ISBN: 978-1-9996465-1-6

8. The correlation between patient reported outcome measures and advanced biomechanics in knee osteoarthritis. Tawy G F, Simons MR, Biant LC, Rowe PJ The Knee 2017 24(6): VI-VII

9. Stability and advanced kinematics of gait in patients with knee osteoarthritis Tawy G F, Simons MR, Rowe PJ, Biant LC The Knee 2017 24(6): VIII

10. Investigating gait variability and motor control in knee osteoarthritis Tawy GF, Simons MR, Biant LC, Rowe PJ. 2017 XXVI Congress of the International Society of Biomechanics winner of Motor Control Student Award, pp 303.

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