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(MRC CASE) Computer-aided Detection of Osteoporotic Vertebral Fractures in Clinical Images Using Convolutional Neural Network Constrained Local Models (CNN-CLMs)

Faculty of Biology, Medicine and Health

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Prof T Cootes , Dr P Bromiley , Dr Eleni Kariki No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

Osteoporosis is a common, degenerative skeletal disorder that increases the risk of fractures and causes significant morbidity and mortality. Vertebral fractures (VFs) are often an early manifestation of the disease but are significantly under-diagnosed in clinical practice. The University of Manchester (UoM) is currently collaborating with Optasia Medical Ltd. and the Manchester University NHS Foundation Trust to develop ASPIRETM, an out-sourced radiology reporting service for VFs. This uses UoM appearance-modelling technology to assist radiologists by identifying vertebrae in clinical images, measuring their shape, and classifying fractures. However, in recent years, deep learning systems based on convolutional neural networks (CNNs) have shown superior performance on many image analysis tasks.

This project will develop and validate CNNs that can identify VFs in clinical images and could be incorporated into ASPIRETM to improve accuracy and efficiency. Regional CNN regressors that can identify vertebral body outlines will be combined with statistical shape models of the spine, the latter providing a constraint that allows training on relatively small numbers (~1000s) of images whilst dealing with the highly repetitive nature of spinal structures. Through the course of the ASPIRETM project we have acquired a database of over 2000 CT image volumes, each with manual annotations of the vertebral body outlines and diagnoses of spinal pathology. The algorithms will be trained, tested and validated using these images, allowing comparison to the accuracy of our current technology. The aim will be to improve the accuracy and efficiency of the technology used in ASPIRETM, reducing the cost of the service to the NHS.

The student will join a well-established, interdisciplinary team including academic, clinical and commercial partners. They will gain extensive knowledge of state-of-the-art machine vision algorithm development for clinical imaging problems. The project will include a three-month placement with the commercial partner, Optasia Medical Ltd., allowing the student to gain experience of working in both academic and commercial environments, and the translational skills required to transfer research results between the two. They will also have the opportunity to participate in the on-going prospective trials of ASPIRETM, and to feed into an associated health economic study. Finally, they will work with our clinical partners from the Manchester Royal Infirmary and gain extensive knowledge of osteoporosis, particularly the clinical imaging, diagnosis and epidemiology of vertebral fractures and other spinal pathologies.

Entry requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This is a CASE studentship in partnership with Optasia Medical Ltd and will be funded under the MRC Doctoral Training Programme. If you are interested in this project, please make direct contact with the Supervisor to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found here

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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