Joint China Scholarship Council: Finding new drugs to target heart attack and stroke. at University of Sheffield on FindAPhD.com

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Prof P Evans No more applications being accepted Competition Funded PhD Project (Students Worldwide)

Sheffield United Kingdom Biochemistry Biophysics Cardiology Molecular Biology Pharmaceutical Chemistry Pharmacy Structural Biology

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield

About the Project

We invite applications from outstanding graduate students to carry out world class research to help people with heart disease. Your project is built on previous research from our laboratory showing that a transcription factor called c-REL causes the build-up of deposits in arteries (called atherosclerosis), which is the major cause of heart attack and stroke. As a PhD Student, you will work within the vibrant laboratories of Professor Paul Evans (University of Sheffield) and Professor Mike Waring (University of Newcastle) to develop a novel c-REL inhibitory drug that can help people that are at risk of heart attack or stroke. You will receive comprehensive training in state-of-the art cellular and molecular biological approaches (e.g. cloning, next generation sequencing, protein purification/folding) and in biophysical methods (NMR, crystallography) and screening of cyclic peptide libraries. This unique training environment integrating basic molecular biology with drug discovery will provide a particularly strong basis for your career should you wish to follow either academic or industrial paths in the future. You will be joining the next generation of cardiovascular researchers and make a positive impact on the lives of people with heart disease.

Paul Evans

@ProfPaulEvans

Website: https://www.paulevanslab.com/

Mike Waring

@MikeJWaring

Website: https://www.ncl.ac.uk/nes/staff/profile/mikewaring.html

ENTRY REQUIREMENTS

Candidates must have a first or upper second class honors degree or significant research experience.

HOW TO APPLY

Prospective candidates will need to apply for postgraduate research here: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying where they will also be asked to fill in a google form specifically for the Joint China Scholarship Council scheme.

Please clearly state the prospective main supervisor in the respective box and select Infection, Immunity & Cardiovascular Disease as the department.

You must be a national of, and reside in, mainland China (not including Hong Kong or Macau). You must also be intending to return to China once your programme is completed. You will require an unconditional offer from the University of Sheffield including meeting both academic and English language criteria.

Applications close at 5pm on Friday 26th February 2021.

Funding Notes

This scheme provides academically excellent Chinese students with the opportunity to study for a PhD at the University of Sheffield. The scholarships are supported jointly by the China Scholarship Council and the University of Sheffield.
The University of Sheffield will fund tuition fees for 3.5 years. Students are expected to submit their thesis within this period. CSC will fund a grant for living costs for up to 4 years, and one return flight from China to the UK.

References

Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nat Rev Cardiol. 2020 Jan;17(1):52-63.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V. Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun. 2020 Jan 10;11(1):214.
Douangamath, A., Fearon, D., Gehrtz, P. et al. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nat Commun 11, 5047 (2020).

Where will I study?

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