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MRC DiMeN Doctoral Training Partnership: Finding new drugs to target heart attack and stroke.


MRC DiMeN Doctoral Training Partnership

Sheffield United Kingdom Biochemistry Biophysics Cardiology Molecular Biology Pharmaceutical Chemistry Pharmacy Structural Biology

About the Project

We invite applications from outstanding graduate students to carry out world class research to help people with heart disease. Your project is built on previous research from our laboratory showing that a transcription factor called c-REL causes the build-up of deposits in arteries (called atherosclerosis), which is the major cause of heart attack and stroke. As an MRC DiMeN PhD Student, you will work within the vibrant laboratories of Professor Paul Evans (University of Sheffield) and Professor Mike Waring (University of Newcastle) to develop a novel c-REL inhibitory drug that can help people that are at risk of heart attack or stroke. You will receive comprehensive training in state-of-the art cellular and molecular biological approaches (e.g. cloning, next generation sequencing, protein purification/folding) and in biophysical methods (NMR, crystallography) and screening of cyclic peptide libraries. This unique training environment integrating basic molecular biology with drug discovery  will provide a particularly strong basis for your career should you wish to follow either academic or industrial paths in the future. You will be joining the next generation of cardiovascular researchers and make a positive impact on the lives of people with heart disease.

Paul Evans

@ProfPaulEvans

Website: https://www.paulevanslab.com/

Mike Waring

@MikeJWaring

Website: https://www.ncl.ac.uk/nes/staff/profile/mikewaring.html

Benefits of being in the DiMeN DTP:

This project is part of the Discovery Medicine North Doctoral Training Partnership (DiMeN DTP), a diverse community of PhD students across the North of England researching the major health problems facing the world today. Our partner institutions (Universities of Leeds, Liverpool, Newcastle and Sheffield) are internationally recognised as centres of research excellence and can offer you access to state-of the-art facilities to deliver high impact research.

We are very proud of our student-centred ethos and committed to supporting you throughout your PhD. As part of the DTP, we offer bespoke training in key skills sought after in early career researchers, as well as opportunities to broaden your career horizons in a range of non-academic sectors.

Being funded by the MRC means you can access additional funding for research placements, international training opportunities or internships in science policy, science communication and beyond. See how our current DiMeN students have benefited from this funding here: http://www.dimen.org.uk/overview/student-profiles/flexible-supplement-awards

Further information on the programme and how to apply can be found on our website:

https://bit.ly/3lQXR8A 


Funding Notes

Studentships are funded by the Medical Research Council (MRC) for 3.5yrs. Funding will cover UK tuition fees and stipend only. We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme. Please read additional guidance here: View Website
Studentships commence: 1st October 2021
Good luck!

References

Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nat Rev Cardiol. 2020 Jan;17(1):52-63.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V. Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun. 2020 Jan 10;11(1):214.
Douangamath, A., Fearon, D., Gehrtz, P. et al. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nat Commun 11, 5047 (2020).

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