About the Project
In the longer term the gene expression targets of Tra2β in breast cancer that we will identify are potentially useful drug targets.
Training: This project will deliver training in global gene expression analysis (using –omic level bioinformatics skills), cell culture and genome engineering (adding degrons onto the Tra2b gene and CRISPR knockout).
Elliott lab web page https://www.ncl.ac.uk/medical-sciences/people/profile/davidelliott.html
Elliott lab twitter account: https://twitter.com/TheElliottLab
Stuart Wilson Webpage: https://www.sheffield.ac.uk/biosciences/people/mbb-staff/academic/stuart-wilson
Benefits of being in the DiMeN DTP:
This project is part of the Discovery Medicine North Doctoral Training Partnership (DiMeN DTP), a diverse community of PhD students across the North of England researching the major health problems facing the world today. Our partner institutions (Universities of Leeds, Liverpool, Newcastle and Sheffield) are internationally recognised as centres of research excellence and can offer you access to state-of the-art facilities to deliver high impact research.
We are very proud of our student-centred ethos and committed to supporting you throughout your PhD. As part of the DTP, we offer bespoke training in key skills sought after in early career researchers, as well as opportunities to broaden your career horizons in a range of non-academic sectors.
Being funded by the MRC means you can access additional funding for research placements, international training opportunities or internships in science policy, science communication and beyond. See how our current DiMeN students have benefited from this funding here: http://www.dimen.org.uk/overview/student-profiles/flexible-supplement-awards
Further information on the programme and how to apply can be found on our website:
Studentships commence: 1st October 2021
Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ. Elife. 2019 Sep 3;8:e47678. doi: 10.7554/eLife.47678
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Best A, James K, Dalgliesh C, Hong E, Kheirolahi-Kouhestani M, Curk T, Xu Y, Danilenko M, Hussain R, Keavney B, Wipat A, Klinck R, Cowell IG, Cheong Lee K, Austin CA, Venables JP, Chabot B, Santibanez Koref M, Tyson-Capper A, Elliott DJ. Nat Commun. 2014 Sep 11;5:4760. doi: 10.1038/ncomms5760.
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