About the Project
In this PhD project, we will utilize state of the art “-omics” techniques (RNAseq deep sequencing), bio-informatics, high-end imaging, biochemistry and monitoring of clock gene activities, to elucidate roles of circadian rhythm in human disc degeneration and cell-based therapy for treatment of disc degeneration. This project will provide fresh new insights into the function of a core circadian clock factor BMAL1 in IVD physiology and pathogenesis and establish a mechanistic link between ageing and IVD circadian rhythm disruption. More importantly, the project will directly demonstrate the relevance of circadian clocks in human degenerative discs and mesenchymal stem-cell differentiation protocols being currently developed for cell based regenerative strategies for the treatment of disc degeneration and low back pain.
Links to Supervisors:
As an example of recent media coverage for this novel area of research, please follow these links, http://www.dailymail.co.uk/news/article-3722791/A-good-sleep-beat-pain-thanks-24-hour-clock-spine-Discs-cause-agony-sync.html
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
UK applicants interested in this project should make direct contact with the Primary Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.
Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.
To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the MRC Doctoral Training Partnership (DTP) website www.manchester.ac.uk/mrcdtpstudentships
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
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