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(MRC DTP) Decoding the role of vascular smooth muscle cell heterogeneity in cardiovascular disease by single cell genomics

Project Description

Cardiovascular disease is the leading cause of death worldwide. Vascular smooth muscle cells (VSMC) are implicated in the pathogenesis of several types of vascular diseases, such as aneurysm, atherosclerosis, vascular calcification and congenital vascular disease. VSMCs in different blood vessels are heterogeneous, behave differently in healthy and diseased states and derive from different embryonic progenitors. This project will use the latest technologies (single cell RNA-seq, single cell ATAC-seq, spatial transcriptomics) to resolve VSMC subpopulations in the developing human embryo, trace their lineage history and uncover the regulatory programs responsible for their differentiation. The discovery and characterization of disease-relevant transcriptional and chromatin signatures in VSMC subpopulations will help clarifying the basis of human cardiovascular pathology, enable diagnostic solutions for cardiovascular disease and facilitate reverse engineering of human tissues for regenerative purposes.

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the MRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the MRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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