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MRC DTP iCASE PhD project : VASCPIPE- Optimised Flow and Access in Vascular conduits


   School of Life Sciences

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  Prof G Houston, Prof Z Huang  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

Dundee United Kingdom Biomedical Engineering Biophysics

About the Project

VASCPIPE Vision: To develop, test and validate designs of the Spiral Laminar Flow (SLF™) Early Cannulation Access Graft (ECAG) and a Hybrid Stent Graft (HSG) for Vascular Access in patients with Kidney Failure for wider commercialisation with a global medical device company.

This PhD will focus on the Computing and Imaging Science developments that relate to the development of the Vascular Flow Technologies (VFT) spiral flow graft products. In particular in the first stage, it will develop the computational fluid dynamics and early simulations of implantation using clinically derived human imaging datasets to determine optimised flow conditions and reduction of conduit and downstream wall adverse conditions that result in device failure. In the second stage the PhD will use the unique Thiel human cadaveric models to assess flow optimisation using advanced imaging techniques to determine design validation.

The academic team comprises a leading translational research group of biomedical engineers, computer scientists, clinical scientists and NHS clinicians within the Institute for Medical Science and Technology (www.imsat.org). In addition the Image Guided Therapy Research Facility led by Professor Graeme Houston offers an advanced surgical intervention facility with unique access to the Thiel human cadaveric model which offers both advanced imaging and full perfused whole body model for medical device design and testing.

 The University of Dundee has a well established doctoral student programme in biomedical technology through the translational integration of the contributing university departments and schools of engineering, computing, Institute for Medical Science and Technology, Centre for Anatomy and Human Identification, School of Medicine. The University of Dundee is the top UK Medical School, 5th in UK for Medtech and 1st in UK for clinical impact of research. The students have experienced supervisory teams, whom they meet on a regular basis to ensure appropriate academic approach and progress. VFT’s ethos for organisational growth is to develop and nurture PhD students who then become employees of the company.

The project will be developed as iCASE partnership in collaboration with Vascular Flow Technologies Ltd.

Please apply by completing our School of Life Sciences application form - details can be found at the following website:

PhD Studentships | School of Life Sciences (dundee.ac.uk)

PLEASE NOTE:

Applications for this round of recruitment are open to candidates who meet the following eligibility criteria –

·      Be a UK National (meeting residency requirements), or

·      Have settled status, or

·      Have pre-settled status (meeting residency requirements), or

·      Have indefinite leave to remain or enter

Further information on eligibility and residency requirements can be found in the UKRI Training Grant Terms & Conditions (found here: https://www.ukri.org/wp-content/uploads/2021/03/UKRI-150321-TrainingGrantsTermsConditions-Mar2021.pdf)

and accompanying guidance documentation (found here: https://www.ukri.org/wp-content/uploads/2020/10/UKRI-291020-guidance-to-training-grant-terms-and-conditions.pdf)


References

Houston, G., Macdonald, C., Hellmuth, R., Priba, L., Murphy, E., Gandy, S., Matthew, S. & Ross, R. Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques. 2020, Cardiovascular Engineering and Technology. 10.1007/s13239-020-00473-z.
MacDonald CJ, Ross R, Houston JG. Increased Brachial Artery Compliance After Arteriovenous Fistula Creation as Measured by Shear Wave Elastography: Results From a Feasibility Study. J Ultrasound Med. 2019 Nov 14. doi: 10.1002/jum.15169
McDonald CM, Gandy SJ, Avison ECM, Matthew S, Ross R, Houston JG. Non-contrast MRI methods as a tool for the pre-operative assessment and surveillance of the arterio-venous fistula for haemodialysis. August 2018MAGMA Magnetic Resonance Materials in Physics Biology and Medicine. DOI: 10.1007/s10334-018-0700-1.