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(MRC DTP) Improved identification of brain tumour extent on advanced multi-modality medical images

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  • Full or part time
    Dr R Hinz
    Dr David Coope
    Dr M Asselin
    Prof A Jackson
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Gliomas are primary brain tumours which span a spectrum from comparatively slow growing tumours in young adults to highly aggressive tumours presenting later in life. Despite aggressive treatment combining surgery followed by radio-chemotherapy, gliomas recur at the edges of the resection. Cure of these tumours thus remains impossible which together with the poor prognosis of the most common subtype (about a year for glioblastoma) leads to a disproportionately high socio-economic impact. Treatment planning relies on the radiological identification of the tumour extent typically with Magnetic Resonance Imaging (MRI). Clinically used brain imaging techniques based on cerebral blood flow and capillary leakage are limited in detecting tumour cell invasion into the tissue surrounding the tumour.
Advanced MRI and Positron Emission Tomography (PET) techniques have been used to acquire quantitative brain imaging data. For example, tissue relaxivity and diffusivity characteristics using MRI, amino acid transport and neuroinflammation using PET for which the research team has extensive experience.
The aim of this PhD project is to improve the identification of malignant brain tissue in human MR and PET images and to better characterise the infiltration of the tumour environment by cancer cells in order to guide treatment planning. This PhD studentship is based in biomedical imaging science with an emphasis on data analysis methodology for tissue classification, tumour edge detection and multi-parametric mapping. It provides training opportunities in image processing and segmentation, tracer kinetic analysis and statistical imaging methods. It is embedded in an interdisciplinary research environment of clinical scientists and imaging experts based at the Imaging Facilities at the University of Manchester with close links to the Salford Royal NHS Foundation Trust and other hospitals within the Manchester Academic Health Sciences Centre. As part of the training, the student will be encouraged to attend relevant course units from the MSc in Medical Imaging Science.

• Neuro Oncology at Manchester https://www.bmh.manchester.ac.uk/research/domains/neuroscience-mental-health/neurooncology/
• University of Manchester Imaging Facilities https://sites.manchester.ac.uk/imaging-facilities/
• Manchester Neuroimaging https://sites.manchester.ac.uk/mcrneuroim/

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the MRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the MRC DTP website www.manchester.ac.uk/mrcdtpstudentships

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.



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