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(MRC DTP) Modelling the impact on costs and outcomes on enhancing early detection in lung and colorectal cancers


Project Description

Background: Cancer early detection (ED) and cancer health economics are key MRCR themes and central to the successful CRUK Manchester MERCADO award (includes Renehan & Payne). There is a paucity of individual-patient level models available to allow evaluation of the cost-effectiveness of interventions to enhance ED and its anticipated downstream effects on down-staging and improved outcome. Such a model will greatly facilitate the translation and targeting of, for example, new biomarker tests into clinical practice.
Aims This 3-year PhD proposal (for a clinical student) will:
1. Use the Clinical Practice Research Dataset (CPRD: 2006 to 2015) to identify [through linkage with the National Cancer Registration and Analysis Service (NCRAS); Office of National Statistics (ONS); Hospital Episode Statistics (HES)] and model patients with lung and colorectal cancer;
2. Through the linked databases, capture individual-level data on confounding factors – patient-related (co-morbidities; smoking) and treatment-related (stage, treatment modality);
3. Using multi-state modelling and Hidden Markov Models, derive estimates of lifetime survival and quality-adjusted life years (QALYs);
4. Build decision analytical models to account for plausible changes in stages at diagnosis brought about by an enhanced ED intervention.
Study design: By PhD commencement (Oct 2020), the Renehan-Payne collaboration will be supervising two projects in cancer health economics. From that platform, there will be four workstreams (WSs): (i) using the CPRD linked with NCRAS, ONS and HES to characterise the natural histories of lung and colorectal cancer patients (WS1); ii) using transition multi-state modelling to estimate lifetime costs accounting for stage, treatment, co-morbidities, lifestyle (e.g. smoking) (WS2); (iii) estimate QALYs (WS3); and (iv) build decision analytical models to account for plausible changes in stages at diagnosis brought about by an enhanced ED intervention, introduced at different ages.
Impact: This thesis will be used to evaluate the optimum potential of new ED interventions.

https://www.research.manchester.ac.uk/portal/en/researchers/andrew-renehan(1e41c673-eca3-4338-b5d7-33f9ecf6e335)/projects.html?period=running

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the MRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the MRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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